HSEGHMM: HIDDEN MARKOV MODEL-BASED ALLELE-SPECIFIC COPY NUMBER ALTERATION ANALYSIS ACCOUNTING FOR HYPERSEGMENTATION

hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation

Abstract Background Somatic copy number alternation (SCNA) is a common feature of the cancer genome and is associated with cancer etiology and prognosis.The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and the tumor purity.Next generation sequencing platf

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Coping Styles and Defense Mechanisms Mediate Associations Between Exposure to Adverse Childhood Experiences and CPTSD Symptoms in Faroese Adolescents

The experience of several read more adverse childhood experiences (ACEs) has been shown to be associated with Post-Traumatic Stress Disorder (PTSD) and Disturbances in Self-Organization (DSO) symptoms among adolescents.Defense mechanisms and coping styles are psychological processes involved in the association of ACEs with PTSD and DSO symptoms.How

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SUSTAINABLE ENTREPRENEURSIP AND ENVIRONMENTAL DYNAMISM OF SELECTED METER MANUFACTURING COMPANIES IN LAGOS STATE

In the fields of business and environmental studies, sustainable entrepreneurship and environmental dynamism are inevitable concepts that drives the economy.Sustainable businesses may need to be especially inventive in highly dynamic circumstances, utilizing their knowledge of sustainability to foresee and adapt to changes.Therefore, the study was

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Exploring the Dimensions of Academic Human Capital: Insights into Enhancing Higher Education Environments in Egypt

The performance of higher education institutions is significantly influenced by their academic human capital (AHC), which encompasses research competencies, dynamic capacity, working capacity, critical thinking, social capital, and external relations.This study aims to investigate the interrelationships among these dimensions and their collective i

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Comparative pangenome analysis of Enterococcus faecium and Enterococcus lactis provides new insights into the adaptive evolution by horizontal gene acquisitions

Abstract Background Enterococcus faecium and E.lactis are phylogenetically closely related lactic acid bacteria that are ubiquitous in nature and are known to be beneficial or pathogenic.Despite their considerable industrial and clinical importance, comprehensive studies on their evolutionary relationships and genomic, metabolic, and pathogenic tra

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